EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.61 | expression in HEK293 cell | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.61 | D374Y | naturally occurring gain-of-function mutant causes severe hypercholesterolemia | Homo sapiens |
3.4.21.61 | S127R | naturally occurring gain-of-function mutant causes severe hypercholesterolemia | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.61 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.61 | low density lipoprotein receptor + H2O | PCSK9 binding to cell surface low density lipoprotein receptor cannot be described by a simple bimolecular reaction. Data suggest the presence of two populations of binding site | Homo sapiens | ? | - |
? |